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Image Search Results
Journal: Neural Regeneration Research
Article Title: An innovative treatment for hypoxic-ischemic encephalopathy: Silk fibroin nanomaterials improve neural stem cell axon formation and facilitate cognitive improvement
doi: 10.4103/nrr.nrr-d-24-01178
Figure Lengend Snippet: Figure 6 |Efficacy assessments in the HIE rat model. (A) Animal experiment timeline. (B) Whole-brain and HE-staining images. The infarct area was significantly reduced in both the hNSC direct injection group and the hNSC-loaded SF hydrogel group compared with the HIE group. Scale bars: 1 cm. (C) Representative IHC images of GFAP in the cerebral cortex and hippocampal CA1, DG, and CA3 regions (scale bars: 100 μm). (D) Number of GFAP-positive cells. Data are presented as the mean ± SD (n = 10/group). *P < 0.05, **P < 0.01, ***P < 0.001 (one-way analysis of variance followed by the least significant difference post hoc test or Welch test with Dunnett post hoc test). CTX: Cerebral cortex; DG: dentate gyrus; ELISA: enzyme-linked immunosorbent assay; GFAP: glial fibrillary acidic protein; HE staining: hematoxylin–eosin staining; HIE: hypoxic-ischemic encephalopathy; hNSC: human-derived neural stem cell; IF: immunofluorescence; IHC: immunohistochemistry; ns: not significant; NSC: neural stem cell; SF: silk fibroin; STI: stereotaxic injection.
Article Snippet: NSC differentiation efficiency was evaluated using a human/mouse/rat neural
Techniques: Staining, Injection, Enzyme-linked Immunosorbent Assay, Derivative Assay, Immunofluorescence, Immunohistochemistry
Journal: Neural Regeneration Research
Article Title: Association between p75 neurotrophin receptor gene expression and cell apoptosis in tissues surrounding hematomas in rat models of intracerebral hemorrhage
doi: 10.3969/j.issn.1673-5374.2012.08.005
Figure Lengend Snippet: Hematoxylin-eosin (HE) and immunohistochemical staining of brain tissue surrounding hematomas after intracerebral hemorrhage (ICH). (A) The yellow arrow indicates neuronal apoptosis as shown by darkly stained cytoplasm and chromatin margination around the hematoma. The blue arrow shows the infiltration of neutrophils, suggesting that inflammation occurs around the hematoma after ICH (HE staining, × 400). (B) After ICH, brain tissue edema around the hematoma occurs as indicated by light staining and cell numbers decrease close to the hematoma, (HE staining, × 200). (C) Perivascular edema, suggesting vascular edema after ICH (HE staining, × 400). (D) p75 neurotrophin receptor is mainly expressed in the cytoplasm of neurons in the control (HE staining, × 400). (E–H) Immunohistochemical staining at 6, 24, 72 hours, and 10 days after ICH, respectively (× 400).
Article Snippet: Immunohistochemical procedures were performed according to the protocol for the
Techniques: Immunohistochemical staining, Staining, Control